In 1792, a house in the occupation of a certain Richard Tew of Audlem was certified as 'a place of worship under the Toleration Act'. It is reported that in 1805 the American evangelist, Lorenzo Dow, staged a campaign in the village, and that in 1820 the 'Circuit Missioner', Nathaniel Turner, also focussed his efforts here. Such work apparently bore fruit. By 1822 Audlem was making a contribution (of ten shillings) to the Nantwich Circuit and, in 1829, fifty to sixty Wesleyan Methodists were recorded as dissenters residing in the parish. It was presumably these Methodists that built the first Methodist chapel in Audlem - a Wesleyan chapel - that opened in 1833. This was in Stafford Street, near to Ash Tree House.

The Wesleyans were not the only Methodists in the village. In 1845 the Burland Circuit gave permission for a Primitive Methodist Chapel to be built. This was opened in Cheshire Street in 1848. Both buildings soon became inadequate. In 1863 the original Wesleyan chapel was sold and the present chapel opened in Shropshire Street, with a schoolroom being added and a new organ installed in 1876. And in 1871 the Primitive chapel in Cheshire Street was taken down and a larger building erected on the same site.

1933 saw the coming together of the main strands of Methodism. In 1934 a local amalgamation scheme made the minister at the Primitive Chapel minister of both societies. The following year the two societies became one, deciding to settle in the Wesleyan premises in Shropshire Street. Extensive refurbishment followed. The space at the front of the chapel was widened to accommodate choir stalls. A new organ chamber was added to take the organ (improved and enlarged) from the Primitive chapel. The chapel was completely refurnished in oak and a vestibule, vestry and kitchen added. Additional land was bought to allow for a car park and garden. The renewed premises were opened in 1937.

In the post-war years, Sunday School and youth work, music, and an active Sisterhood all characterised Church life. The later decades of the twentieth century saw steady growth in membership. A religious musical was added to the programme in the 1980s and this has since become an annual event. The premises have continued to be modernised. In 1998 a substantial extension was completed, providing a new entrance, meeting room, vestry and toilets. Further refurbishment work was carried out in 2002, including the complete overhaul of the pipe organ and the fitting of a new kitchen. In 2006 a programme of alterations significantly upgraded the chapel part of the premises.